BackgroundHIV molecular epidemiology is increasingly recognized as a vital source of information for understanding HIV transmission dynamics. Despite extensive use of these data-intensive techniques in both research and public health settings, the ethical issues associated with this science have received minimal attention. As the discipline evolves, there is reasonable concern that existing ethical and legal frameworks and standards might lag behind the rapid methodological developments in this field. This is a follow-up on our earlier work that applied a predetermined analytical (...) framework to examine the perspectives of a sample of scientists from the fields of epidemiology, public health, virology and bioethics on key ethical issues associated with HIV molecular epidemiology in HIV network research.MethodsFourteen in-depth interviews were conducted with scientists from the fields of molecular epidemiology, public health, virology and bioethics. Inductive analytical approaches were applied to identify key themes that emerged from the data.ResultsOur interviewees acknowledged the potential positive impact of molecular epidemiology in the fight against HIV. However, they were concerned that HIV phylogenetics research messages may be incorrectly interpreted if not presented at the appropriate level. There was consensus that HIV phylogenetics research presents a potential risk to privacy, but the probability and magnitude of this risk was less obvious. Although participants acknowledged the social value that could be realized from the analysis of HIV genetic sequences, there was a perceived fear that the boundaries for use of HIV sequence data were not clearly defined.ConclusionsOur findings highlight distinct ethical issues arising from HIV molecular epidemiology. As the discipline evolves and HIV sequence data become increasingly available, it is critical to ensure that ethical standards keep pace with biomedical advancements. We argue that the ethical issues raised in this study, whether real or perceived, require further conceptual and empirical examination. (shrink)

The reduced costs of DNA sequencing and the use of such data for HIV‐1 clinical management and phylogenetic analysis have led to a massive increase of HIV‐1 sequences in the last few years. Phylogenetic analysis has shed light on the origin, spread and characteristics of HIV‐1 epidemics and outbreaks. Phylogenetic analysis is now also being used to advance our knowledge of the drivers of HIV‐1 transmission in order to design effective interventions. However, HIV phylogenetic analysis presents unique ethical challenges, which (...) have not been fully explored. This review presents an analysis of what appear to be key ethical issues in HIV phylogenetics in the hope of stimulating further conceptual and empirical work in this rapidly emerging area. We structure the review using the Emanuel Framework, a systematic, holistic framework, which has been adapted for use in developing countries, which bear the brunt of the HIV‐1 pandemic. (shrink)

The notion of normal proof theory, and yet it has been somewhat neglected by the systems of equational logic. The intention here is then to show the normalization procedure for the equational logic of the Labelled Natural Deduction system . With this we believe we are making a step towards filling a gap in the literature on equational logic. Besides presenting a normalization procedure for the LND equational fragment, we employ a new method to prove the normalization theorems for equational (...) logic: proof transformation by rewriting, based on a algebraic calculus on the 'rewrite reasons'. (shrink)

It is assumed that social bonds in humans have consequences for virtually all aspects of behavior. Social touch-based contact, particularly hand caressing, plays an important role in social bonding. Pre-programmed neural circuits likely support actions (or predispositions to act) towards caressing contacts. We searched for pre-set motor substrates towards caressing by exposing volunteers to bonding cues and having them gently stroke a very soft cloth, a caress-like movement. The bonding cues were pictures with interacting dyads and the control pictures presented (...) non-interacting dyads. We focused on the readiness potential, an electroencephalographic marker of motor preparation that precedes movement execution. The amplitude of the readiness potential preceding the grasping of pleasant emotional-laden stimuli was previously shown to be reduced compared with neutral ones. Fingers flexor electromyography measured action output. The rationale here is that stroking the soft cloth when previously exposed to bonding cues, a compatible context, would result in smaller amplitudes of readiness potentials, as compared to the context with no such cues. Exposure to the bonding pictures increased subjective feelings of sociability and decreased feelings of isolation. Participants who more frequently engage in mutual caress/groom a “significant other” in daily life initiated the motor preparation earlier, reinforcing the caress-like nature of the task. As hypothesized, readiness potentials preceding the caressing of the soft cloth were significantly reduced under exposure to bonding as compared to control pictures. Furthermore, an increased fingers flexor electromyographic activity was identified under exposure to the former as compared to the latter pictures. The facilitatory effects are likely due to the recruitment of pre-set cortical motor repertoires related to caress-like movements, emphasizing the distinctiveness of neural signatures for caress-like movements. (shrink)

Proximity and interpersonal contact are prominent components of social connection. Giving affective touch to others is fundamental for human bonding. This brief report presents preliminary results from a pilot study. It explores if exposure to bonding scenes impacts the activity of specific muscles related to physical interaction. Fingers flexion is a very important component when performing most actions of affectionate contact. We explored the visuo-motor affective interplay by priming participants with bonding scenes and assessing the electromyographic activity of the fingers (...) flexor muscle, in the absence of any overt movements. Photographs of dyads in social interaction and of the same dyads not interacting were employed. We examined the effects upon the electromyographical activity: during the passive exposure to pictures, and during picture offset and when expecting the signal to perform a fingers flexion task. Interacting dyads compared to matched non-interacting dyads increased electromyographic activity of the fingers flexor muscle in both contexts. Specific capture of visual bonding cues at the level of visual cortex had been described in the literature. Here we showed that the neural processing of visual bonding cues reaches the fingers flexor muscle. Besides, previous visualization of bonding cues enhanced background electromyographic activity during motor preparation to perform the fingers flexion task, which might reflect a sustained leakage of central motor activity downstream leading to increase in firing of the respective motor neurons. These data suggest, at the effector level, an implicit visuo-motor connection in which social interaction cues evoke intrinsic dispositions toward affectionate social behavior. (shrink)

To most of us – believers and non-believers alike – the possibility of a perfect God co-existing with the kinds of evil that we see calls out for explanation. It is unsurprising, therefore, that the belief that God must have justifying reasons for allowing all the evil that we see has been a perennial feature of theistic thought. Recently, however, a growing number of authors have argued that the existence of a perfect God is compatible with the existence of gratuitous (...) evil. Given powerful, millenia-long sensibilities about power and love and justice, it isn’t hard to find that suggestion simply incredible. Nonetheless, in this paper I will argue that the most prominent theistic alternatives to what has seemed incredible to most of us throughout most of history are themselves patently unacceptable for the theist as well. On any of the most widely accepted accounts of how God could have justifying reasons for permitting some evils, God’s existence means that we have justifying reasons for perpetrating and allowing every evil that we see. That's hard to swallow too. If I’m right about all of this, then two competing outcomes seem to present themselves as a possible result. On the one hand, for the theist, the apparently outrageous suggestion that the existence of a perfect God is compatible with gratuitous evil no longer looks like it faces a formidable, hard-to-resist alternative. On the other hand, some like me might think that my arguments go no distance at all towards dispelling the incredibility of the gratuitous evil nouvelle vague. On this line, theism may seem now to be between the rock and the hard place: it seems hard to make sense of the existence of a perfect God whether or not He has justifying reasons for allowing all the evil that we see. (shrink)

The geometric system of deduction called N-Graphs was introduced by de Oliveira in 2001. The proofs in this system are represented by means of digraphs and, while its derivations are mostly based on Gentzen's sequent calculus, the system gets its inspiration from geometrically based systems, such as the Kneales' tables of development, Statman's proofs-as-graphs, Buss' logical flow graphs, and Girard's proof-nets. Given that all these geometric systems appeal to the classical symmetry between premises and conclusions, providing an intuitionistic version (...) of any of these is an interesting exercise in extending the range of applicability of the geometric system in question. In this article we produce an intuitionistic version of N-Graphs, based on Maehara's LJ' system, as described by Takeuti. Recall that LJ' has multiple conclusions in all but the essential intuitionistic rules, e.g., implication right and negation right. We show soundness and completeness of our intuitionistic N-Graphs with respect to LJ'. We also discuss how we expect to extend this work to a version of N-Graphs corresponding to the intuitionistic logic system FIL (Full Intuitionistic Logic) of de Paiva and Pereira and sketch future developments. (shrink)

Paul Silva has recently argued that doxastic justification does not have a basing requirement. An important part of his argument depends on the assumption that doxastic and moral permissibility have a parallel structure. I here reply to Silva's argument by challenging this assumption. I claim that moral permissibility is an agential notion, while doxastic permissibility is not. I then briefly explore the nature of these notions and briefly consider their implications for praise and blame.

Deontological evidentialism is the claim that we ought to form and maintain our beliefs in accordance with our evidence. In this paper, I criticize two arguments in its defense. I begin by discussing Berit Broogard’s use of the distinction between narrow-scope and wide-scope requirements against W.K. Clifford’s moral defense of. I then use this very distinction against a defense of inspired by Stephen Grimm’s more recent claims about the moral source of epistemic normativity. I use this distinction once again to (...) argue that Hilary Kornblith’s criticism of Richard Feldman’s defense of is incomplete. Finally, I argue that Feldman’s defense is insensitive to the relation between normative requirements and privileged values: values that have normative authority over us. (shrink)

Skeptical theism, broadly construed, is an attempt to leverage our limited cognitive powers, in some specified sense, against “evidential” and “explanatory” arguments from evil. Since there are different versions of these kinds of arguments, there are correspondingly different versions of skeptical theism. In this paper, I briefly explain three versions of these arguments from evil (two from William Rowe and one from Paul Draper) and the three versions of skeptical theism tailor-made to block them (from Stephen Wykstra, Michael Bergmann, and (...) Peter van Inwagen). (shrink)

This paper defends a novel account of how to determine the intrinsic value of possible worlds. Section 1 argues that a highly intuitive and widely accepted account leads to undesirable consequences. Section 2 takes the first of two steps towards a novel account by clarifying and defending a view about value-contribution that is based on some of W. D. Ross’ claims about the value of pleasure. Section 3 takes the second step by clarifying and defending a view about value-suppression that (...) is based on Ross’ claims about the interplay between prima-facie duties. Section 4 states and defends the account that I call Rossian Totalism. According to this account, the atoms of intrinsic value within a world only sometimes contribute their intrinsic value to the value of that world. (shrink)

Skeptical theism, broadly construed, is an attempt to leverage our limited cognitive powers, in some specified sense, against “evidential” and “explanatory” arguments from evil. Since there are different versions of these kinds of arguments, there are correspondingly different versions of skeptical theism. In this paper, I consider four challenges to three central versions of skeptical theism: (a) the problem of generalized skepticism, (b) the problem of moral skepticism, (c) the problem of unqualified modal skepticism, and (d) the challenge from Bayesian (...) epistemology. (shrink)

Deontological evidentialism is the claim that S ought to form or maintain S’s beliefs in accordance with S’s evidence. A promising argument for this view turns on the premise that consideration c is a normative reason for S to form or maintain a belief that p only if c is evidence that p is true. In this paper, I discuss the surprising relation between a recently influential argument for this key premise and the principle that ought implies can. I argue (...) that anyone who antecedently accepts or rejects this principle already has a reason to resist either this argument’s premises or its role in support of deontological evidentialism. (shrink)

Deontological internalism is the family of views where justification is a positive deontological appraisal of someone's epistemic agency: S is justified, that is, when S is blameless, praiseworthy, or responsible in believing that p. Brian Weatherson discusses very briefly how a plausible principle of ampliative transmission reveals a worry for versions of deontological internalism formulated in terms of epistemic blame. Weatherson denies, however, that similar principles reveal similar worries for other versions. I disagree. In this article, I argue that plausible (...) principles of ampliative transmission reveal a worry for deontological internalism in general. (shrink)

BackgroundThe ARRIVE (Animal Research: Reporting of In Vivo Experiments) guidelines are widely endorsed but compliance is limited. We sought to determine whether journal-requested completion of an ARRIVE checklist improves full compliance with the guidelines.MethodsIn a randomised controlled trial, manuscripts reporting in vivo animal research submitted to PLOS ONE (March–June 2015) were randomly allocated to either requested completion of an ARRIVE checklist or current standard practice. Authors, academic editors, and peer reviewers were blinded to group allocation. Trained reviewers performed outcome adjudication (...) in duplicate by assessing manuscripts against an operationalised version of the ARRIVE guidelines that consists 108 items. Our primary outcome was the between-group differences in the proportion of manuscripts meeting all ARRIVE guideline checklist subitems.ResultsWe randomised 1689 manuscripts (control: n = 844, intervention: n = 845), of which 1269 were sent for peer review and 762 (control: n = 340; intervention: n = 332) accepted for publication. No manuscript in either group achieved full compliance with the ARRIVE checklist. Details of animal husbandry (ARRIVE subitem 9b) was the only subitem to show improvements in reporting, with the proportion of compliant manuscripts rising from 52.1 to 74.1% (X2 = 34.0, df = 1, p = 2.1 × 10−7) in the control and intervention groups, respectively.ConclusionsThese results suggest that altering the editorial process to include requests for a completed ARRIVE checklist is not enough to improve compliance with the ARRIVE guidelines. Other approaches, such as more stringent editorial policies or a targeted approach on key quality items, may promote improvements in reporting. (shrink)

Resumo: O objetivo do presente artigo é contrapor à acusação de tecnofóbico, erroneamente dirigida a Hans Jonas, a sua proposta de uma ethical turn da tecnologia, cujas bases estariam na capacidade ética de impor contenções ao avanço utópico do progresso técnico, algo que leva a ética da responsabilidade ao polêmico conceito de “heurística do temor”. Para tanto, parte-se de um exame sobre o projeto jonasiano de uma filosofia da tecnologia, cuja terceira perspectiva seria valorativa, sendo esta a que ele melhor (...) desenvolveu. A partir daí, analisa-se qual seria o valor da tecnologia, com base no ponto de vista da vida para então se examinar, estrategicamente, a posição de Gerard Lebrun, para quem Jonas estaria entre os filósofos tecnofóbicos. O intuito, nesse caso, é demonstrar a incoerência de tal interpretação, precisamente porque o pensador francês, com grande atuação no Brasil, confunde a proposta da reorientação ética com a imposição de um poder exterior, de cunho paralisante.: The purpose of this article is to counter against the accusation of technophobic, wrongly directed to Hans Jonas, his proposal for an ethical turn of technology, whose bases would be on the ethical capacity to impose restraint on the utopian advance of technical progress, something that leads to the ethics of responsibility to the controversial concept of “heuristic of fear”. To do so, we started from an examination of the Jonasian project of a philosophy of technology, whose third perspective would be valuable, which is the one he developed best. From there, we will analyze what would be the value of technology from the point of view of life and then strategically analyze the position of Gerard Lebrun for whom Jonas should be placed among technophobic philosophers. Our aim, in this case, is to demonstrate the inconsistency of such an interpretation, precisely because the French thinker with an important presence in Brazil, confuses the proposal of ethical reorientation with the imposition of an external power, of a paralyzing type. (shrink)

RESUMO: Pretende-se, com este artigo, analisar como a noção de epistemologias do Sul possibilita pensar também em um ethos sulista, no sentido de que a crise ambiental que assola a civilização tecnológica, crescida sob os auspícios do saber científico moderno, acabou por levar ao maior impasse ético da história humana, aquele que põe em xeque a própria possibilidade de sua existência no futuro. Dessa forma, almeja-se analisar como as comunidades tradicionais representam a concretização fática daquilo que o filósofo alemão Hans (...) Jonas descreveu, em sua proposta de uma ética para a civilização tecnológica: um tipo de vida baseado na frugalidade e na temperança, diante da emergência da crise climática e da urgência de uma nova ética amparada na responsabilidade.: In this article we intend to analyze how the notion of epistemologies of the south enables us to think also of a southern ethos, in the sense that the environmental crisis that plagues the technological civilization, grown under the auspices of modern scientific knowledge ended up leading to the greatest impasse ethics of human history, one that calls into question the very possibility of its existence in the future. In this way, we intend to analyze how traditional communities represent the factual fulfillment of what the German philosopher Hans Jonas described in his proposal for an ethics for technological civilization: a type of life based on frugality and temperance in the face of the emergence of the climate crisis and the urgency of a new ethics based on responsibility. (shrink)

What I call the Doxastic Puzzle, is the impression that while each of these claims seems true, at least one of them must be false: (a) Claims of the form ‘S ought to have doxastic attitude D towards p at t’ are sometimes true at t, (b) If Φ-ing at t is not within S’s effective control at t, then it is false, at t, that ‘S ought to Φ at t’, (c) For all S, p, and t, having doxastic (...) attitude D towards p at t is not within S’s effective control at t. All three natural replies to the puzzle have been pursued. Some have claimed that doxastic attitudes like believing that p are, in fact, within our effective control, or sufficiently so. Others have claimed that doxastic ought-claims, strictly speaking, are always false. And some have denied that effective control is required for the adequacy of doxastic ought-claims in general. I here pursue and examine a different strategy. In the first part of this paper, I argue that these claims are not only each true but actually not in tension with each other in the first place. Instead of attempting to dispel the puzzle, this solution proposes to evade it instead: to solve it by properly understanding, and by thereby accepting without contradiction, all of its constitutive claims. In the second part of the paper, I argue that the evasive strategy forces us to re-think our understanding of the place of normative reasons in epistemology. More exactly, it seems to come at the cost of one central way of thinking about our reasons for having doxastic attitudes, one where such reasons are good-standing exemplars of normative reasons in general. The evasive strategy, that is, threatens to lead us very quickly to a deflationary picture of epistemic normativity: it rescues normative talk, but sacrifices normative substance. I conclude by explaining why I think this is more consequential than some have made it out to be, and by suggesting that these consequences are welcome nonetheless. (shrink)

The claim that ordinary ethical discourse is typically true and that ethical facts are typically knowable seems in tension with the claim that ordinary ethical discourse is about features of reality friendly to a scientific worldview. Cornell Realism attempts to dispel this tension by claiming that ordinary ethical discourse is, in fact, discourse about the same kinds of things that scientific discourse is about: natural properties. We offer two novel arguments in reply. First, we identify a key assumption that we (...) find unlikely to be true. Second, we identify two features of typical natural properties that ethical properties lack. We conclude that Cornell Realism falls short of dispelling the tension between ethical conservativism and ethical naturalism. (shrink)

The development of neuropsychological assessment methods using virtual reality (VR) is a valid and promising option for the detection of cognitive impairment in the older people, focusing on activities composed of tasks of multiple demands. This study verified the association of age, schooling, and general cognitive status on the performance of neurologically healthy older adults in ECO-VR, a virtual reality task of multiple demands for neuropsychological assessment. A total of 111 older adults answered a sociodemographic questionnaire, the Mini Mental State (...) Examination, the Vocabulary subtest of the Wechsler Intelligence Scale for Adults (third edition), and the ECO-VR. Correlation analyses, multiple linear regression, and comparisons between groups (effects by age and schooling groups) were used to evaluate the results. The ECO-VR total score was significantly associated with age, years of education, MMSE, and Vocabulary subtest. The linear regression models identified that age was the main predictor for total score and rule breaking of ECO-VR. According to the univariate analysis, it was identified the main effect of age group and schooling group in the total ECO-VR score, but there was no interaction effect. The results are discussed in order to understand the role of sociodemographic characteristics in the performance of older adults in a virtual reality task of multiple demands. It was also verified the possibility use of virtual reality for neuropsychological assessment of older adults. (shrink)

The distinction between propositional and doxastic justification has been of undisputed theoretical importance in a wide range of contemporary epistemological debates. Yet there are a host of intimately related issues that have rarely been discussed in connection with this distinction. For instance, the distinction not only applies to an individual’s beliefs, but also to group beliefs and to various other attitudes that both groups and individuals can take: credence, commitment, suspension, faith, and hope. Moreover, discussions of propositional and doxastic justification (...) have rarely focused on broader meta-epistemological issues, and yet meta-epistemological positions can have important implications for first-order views about this distinction. This volume addresses these and other issues by bringing together 16 essays that advance the state-of-the-art thinking on propositional and doxastic justification and explore how such thinking shapes and is shaped by a range of issues previously neglected in contemporary epistemology. (shrink)

Hermeneutical injustices, according to Miranda Fricker, are injustices that occur “when a gap in collective interpretive resources puts someone at an unfair disadvantage when it comes to making sense of their social experiences” (Fricker 2007, 1). For Fricker, the relevant injustice in these cases is the very lack of knowledge and understanding experienced by the subject. In this way, hermeneutical injustices are instances of epistemic injustices, the kind of injustice that “wrongs someone in their capacity as a subject of knowledge” (...) (Fricker 2007, 5). In this paper, however, I identify different means by which our hermeneutic activities lead to social injustices, of both a practical and epistemic kind, and I identify different ways in which those injustices manifest themselves. Since Fricker’s use of the notion of “hermeneutical injustices” to denote a well-defined kind of injustice is rightfully well-established, I here refer to the more general kinds of injustices I have in mind as “hermeneutic injustices” instead. (shrink)

Pretende-se com este artigo, demonstrar como o niilismo é um dos conceitos centrais da obra de Hans Jonas. Para isso, analisaremos como o problema se desdobra em sua obra a partir de três perspectivas complementares: a identificação de um niilismo cósmico, cujo primeira aparição são os movimentos gnósticos da Antiguidade tardia e seus impactos sobre o cristianismo primitivo; um niilismo antropológico derivado dessa posição gnóstica e agravado pela filosofia existencialista; um niilismo ético e tecnológico, que tanto serve para diagnosticar a (...) tecnologia como “vontade de ilimitado poder” quanto para compreender a crise ambiental a partir da crise de valores que marca o Ocidente a partir da modernidade. Com isso, o niilismo, interpretado como velle nihil, ou seja, como vontade de negação e, mais especificamente, de destruição, é uma chave interpretativa para a crise ambiental. Dessa forma, a obra de Jonas pode ser considerada como uma tentativa de evitar que o “mais estranho dos hóspedes” destrua a própria morada. (shrink)

Um alinhamento responsável à alguma versão do naturalismo filosófico requer a articulação explicita e cuidadosa de um argumento em sua defesa. Em quatro passos, o texto que segue abaixo expande e examina a validade de um argumento que é frequentemente rascunhado em favor do naturalismo. Como veremos, contudo, a versão do naturalismo que esse argumento nos permite é um pouco diferente dos naturalismos filosóficos mais populares.

Resumo O presente trabalho explora o expediente metodológico aplicado por Merleau-Ponty sobre a obra e a vida de Cézanne: a vida como exigência de uma obra. Discutimos como esse expediente oferece uma chave de leitura para as polêmicas relações entre a vida e a obra nietzschiana, tanto no sentido de verificar como Nietzsche se apresenta internamente à sua obra, quanto para analisar como as circunstâncias de sua vida podem ser interpretadas como exigências do tipo de obra que ele se propôs (...) a formular. Isso nos leva a uma nova estratégia para interpretar também a própria genealogia da obra nietzschiana e, com ele, de toda a história da filosofia.This paper explores the methodological expedient applied by Merleau-Ponty on the work and the life of Cézanne: the life as demand of a work. We discuss how this expedient offers a key to the controversial relations between Nietzsche’s life and Nietzsche’s work, both in terms of how Nietzsche presents himself internally in his work, and in analyzing how the circumstances of his life can be interpreted as demands of the kind of work he has set out to formulate. This brings us to a new strategy to interpret the genealogy of Nietzsche’s work and, with it, of the whole history of philosophy. (shrink)

We propose a simple situation in which the magnetic Aharonov–Bohm potential influences the values of the deficiency indices of the initial Schrödinger operator, so determining whether the particle interacts with the solenoid or not. Even with the particle excluded from the magnetic field, the number of self-adjoint extensions of the initial Hamiltonian depends on the magnetic flux. This is a new point of view of the Aharonov–Bohm effect.

Pretende-se nesse trabalho analisar a crítica do filósofo judeu-alemão Hans Jonas à ideia de progresso e sua perspectiva prática, a ideia de desenvolvimento. Tal perspectiva, segundo o autor, surge de uma mudança no status do saber na era moderna, o que significa reconhecer que a ciência moderna será colocada a serviço dessa ideia. O avanço da problemática ambiental, contudo, exige uma reavaliação ética de tal cenário, fazendo com que a simples utopia do desenvolvimento seja substituída por medidas de prevenção, antecipação (...) dos efeitos negativos e até mesmo por freios voluntários. A política, assim, deve reorientar a ciência em nome de um novo papel: não apenas analisar o fato ocorrido, mas prevê-lo e, quiçá, contribuir para evita-lo. (shrink)

Resumo: Pretende-se neste artigo analisar a noção nietzschiana de filósofo do futuro e sua contribuição para o surgimento do novo homem, tendo em vista, prioritariamente, Além de bem e mal. Para tanto, iniciaremos analisando de que forma esta obra pode ser considerada, segundo a pretensão de seu autor, como uma crítica da modernidade e, consequentemente, de que forma ela se constitui como o manifesto de uma tarefa que Nietzsche define como própria dos filósofos do futuro: a superação do passado, ou (...) seja, das formas metafísicas, dogmáticas e ascéticas que orientaram a filosofia ao longo da história, por meio dos “trabalhadores filosóficos”, que agora devem ceder lugar aos autênticos filósofos, cujas lentes fisiopsicológicas examinam o pensamento como sintoma da saúde ou da doença de seus autores. Com isso, Nietzsche substitui a antiga tarefa do filósofo por uma nova missão. Com essa reflexão, acredita-se margear alguns dos problemas centrais da pesquisa do homenageado desse dossiê, prof. Wilson Antonio Frezzatti Jr.: This paper intends to analyze the Nietzschean notion of philosopher of the future and its contribution to the emergence of the new man, having in mind, primarily, Beyond good and evil. In order to do so, we will begin by analyzing how this work can be considered, according to the author’s intention, as a critique of modernity and, consequently, in what way it constitutes the manifesto of a task that Nietzsche defines as proper to the philosophers of the future: the overcoming of the past, that is, of the metaphysical, dogmatic and ascetic forms that have guided philosophy throughout history, through the “philosophical workers”, who must now give way to authentic philosophers, whose physiopsychological lenses examine thought as symptom of the health or illness of its authors. With this, Nietzsche replaces the philosopher’s old task with a new mission. With this reflection, it is believed that some of the central problems of the research of the honoree of this dossier, prof. Wilson Antonio Frezzatti Jr., are bordered. (shrink)

O ceticismo é por vezes descartado como uma doutrina absurda e merecedora do seu lugar distante na antiguidade. Nada poderia ser menos correto. O ceticismo continua extremamente relevante para o pensamento filosófico e científico de hoje, servindo como um lembrete de que a sabedoria não é barata nem segura. Nesse texto, o meu objetivo principal é reproduzir o raciocínio das discussões clássicas sobre o ceticismo, mas de uma maneira coloquial e contemporânea. Após seguir as linhas de pensamento de Sexto Empírico, (...) René Descartes, e David Hume, eu vou extrair e identificar claramente as teses centrais que marcam as suas ideias. A minha intenção, porém, não é a de sugerir que as suas teses são auto-evidentes, ou incontestáveis, ou até hoje ainda incontestadas. Muito pelo contrário. A minha intenção é produzir um aperitivo ao debate e um convite a discussão. (shrink)

Este livro é o resultado de três anos de debates entre estudiosos interessados em entender o modo como diferentes dimensões da vida podem ser lidas sob a perspectiva da moral. Afinal, embora este tenha sido sempre um tema importante para a sociologia e a antropologia, raros têm sido os esforços brasileiros para a realização de pesquisas empíricas nessa área. Considerando essa lacuna, os autores dos 22 ensaios que fazem parte de Pensando bem se concentram na discussão prática da moral tomada (...) do nosso cotidiano, privilegiando formas de ultrapassar a dicotomia entre abordagens preocupadas com o correto ou justo, de um lado, e aquelas preocupadas com o bom, de outro. (shrink)

Ever since John Locke, philosophers have discussed the possibility of a normative epistemology: are there epistemic obligations binding the cognitive economy of belief and disbelief? Locke's influential answer was evidentialist: we have an epistemic obligation to believe in accordance with our evidence. In this dissertation, I place the contemporary literature on agency and reasons at the service of some such normative epistemology. I discuss the semantics of obligations, the connection between obligations and reasons to believe, the implausibility of Lockean evidentialism, (...) and some of the alleged connections between agency and justification. (shrink)

The problem of modernity occupies a central place in the political reflection carried out by Leo Strauss. Taking this into account, the fundamental aim of this paper is to analyze how this author understood and questioned the philosophic project proposed by modern thinkers. In this sense, we will try to comprehend how, from Strauss´s perspective, modernity, seeking to bring about in history the best political order through the abandonment of traditional esotericism and a radical politicization of philosophy, involves an ideal (...) of rationalization of human life that is ultimately problematic for both society and philosophy. (shrink)

Resumo: O presente artigo tem como objetivo analisar três aspectos do tema do amor na obra de Friedrich Nietzsche. Para tanto, parte de dois pressupostos: [1] o sentimento do amor deve ser entendido como parte do projeto de crítica à metafísica e aos idealismos presentes na moral, na religião e na arte; e como consequência, [2] como crítica às noções do amor que remete à tradição socrático-platônico, judaico-cristã e moderna. Para tanto, os três aspectos daí derivados, mostram que o amor (...) em Nietzsche 1] não é falta, [2] nem negação de si, [3] nem está baseado na ideia de posse; muito pelo contrário, [1] amor é exuberância, [2] depende da fruição de si e [3] está baseado nas diferenças próprias e desigualdades naturais entre os indivíduos. Tal procedimento analítico chega à afirmação da amizade como amor superior, cujo conteúdo remente a um sentimento de homens nobres, precisamente aquilo que se poderia chamar, em Nietzsche, de um grande amor.: This article aims to analyze three aspects of the theme of love in Friedrich Nietzsche’s work. For that, it starts from two assumptions: [1] the feeling of love must be understood as part of the project of criticism of metaphysics and the idealisms present in morals, religion and art; and as a consequence, [2] as a critique of the notions of love that refer to the Socratic-Platonic, Judeo-Christian and modern tradition. The three aspects derived from it, show that love in Nietzsche [1] is not lack, [2] nor self-denial, [3] nor is it based on the idea of possession; quite the contrary, the opposite link, [1] love is exuberance, [2] depends on the enjoyment of oneself and [3] is based on self-differences and natural inequalities between individuals. Such an analytical procedure comes to the affirmation of friendship as a superior love, whose content refers to a feeling of noble men, precisely what could be called, in Nietzsche, great love. (shrink)

Lynne Baker was a trenchant critic of reductionist and physicalist conceptions of the universe, as well as the foremost defender of the constitution view of human persons. Baker was a staunch defender of a kind of practical realism, or what she sometimes called a metaphysics of everyday life. And it was this general “common sense” philosophical outlook that underwrote her non-reductionist, constitution view of reality. Whereas most of her contemporaries were given to metaphysical reductionism and eliminativism, born of a penchant (...) for so-called Quinean desert landscapes, Baker was unapologetic and philosophically deft in her defense of ontological pluralism. This volume honors Baker’s work by bringing together 16 critical essays by some of her students, colleagues, interlocutors, and friends. The essays fall into four areas, each an area to which Baker made unique and influential contributions: Practical Realism about the Mind, The Constitution View of Human Persons, The First Person Perspective, and God, Christianity and Naturalism. (shrink)

Strong evidence shows that exposure and engagement with the natural world not only improve human wellbeing but can also help promote environmentally friendly behaviors. Human-nature relationships are at the heart of global agendas promoted by international organizations including the World Health Organization’s “One Health” and the United Nations “Ocean Decade.” These agendas demand collaborative multisector interdisciplinary efforts at local, national, and global levels. However, while global agendas highlight global goals for a sustainable world, developing science that directly addresses these agendas (...) from design through to delivery and outputs does not come without its challenges. In this article, we present the outcomes of international meetings between researchers, stakeholders, and policymakers from the United Kingdom and Brazil. We propose a model for interdisciplinary work under such global agendas, particularly the interface between One Health and the UN Ocean Decade and identify three priority research areas closely linked to each other: human-nature connection, conservation-human behavior, and implementation strategies. We also discuss a number of recommendations for moving forward. (shrink)

Our goal was to explore self‐care practices among men who have sex with men in the context of Mpox in Brazil. This study used qualitative research methods, including interviews and thematic analysis, to collect and analyze data from male participants across the Brazilian territory. The narratives unveil men's perspectives on self‐care, risk reduction, and health beliefs during the Mpox pandemic. Our findings highlight a multifaceted approach to self‐care among men, encompassing hygiene, physical contact management, mask usage, skin lesion vigilance, and (...) adherence to official guidelines. Men's attitudes toward sexual behaviors emphasize the importance of reducing sexual partners, practicing safe sex, and combating misinformation through accurate information dissemination. The development of these behaviors and self‐care practices can be facilitated by nurses guided by Dorothea Orem's Self‐Care Theory, supported by patient‐centered care, with strategies to address and confront the stigma associated with the disease and provide emotional support. Thus, the study underscores the pivotal role of self‐care in mitigating infection risks, especially in the context of emerging infectious diseases. It acknowledges the impact of socio‐cultural factors and healthcare policies on men's preventive measures. However, it also recognizes limitations, such as potential bias due to stigma concerns and a nonrepresentative sample. Ultimately, the research advocates for tailored education, promotion of gender equity, and healthcare empowerment to effectively manage health risks in such contexts. (shrink)

Automated classification of legal documents has been the subject of extensive research in recent years. However, this is still a challenging task for long documents, since it is difficult for a model to identify the most relevant information for classification. In this paper, we propose a two-stage supervised learning approach for the classification of petitions, a type of legal document that requests a court order. The proposed approach is based on a word-level encoder–decoder Seq2Seq deep neural network, such as a (...) Bidirectional Long Short-Term Memory (BiLSTM) or a Bidirectional Encoder Representations from Transformers (BERT) model, and a document-level Support Vector Machine classifier. To address the challenges posed by the lengthy legal documents, the approach introduces a human-in-the-loop approach, whose task is to localize and tag relevant segments of text in the word-level training part, which dramatically reduces the dimension of the document classifier input vector. We performed experiments to validate our approach using a real-world dataset comprised of 270 intermediate petitions, which were carefully annotated by specialists from the 15th civil unit of the State of Alagoas, Brazil. Our results revealed that both BiLSTM and BERT-Convolutional Neural Networks variants achieved an accuracy of up to 95.49%, and also outperformed baseline classifiers based on the Term Frequency–Inverse Document Frequency test vectorizer. The proposed approach is currently being utilized to automate the aforementioned justice unit, thereby increasing its efficiency in handling repetitive tasks. (shrink)

Enterprise Risk Management involves the process of identification, evaluation, treatment, and communication regarding risks throughout the enterprise. To support the tasks associated with this process, several frameworks and modeling languages have been proposed, such as the Risk and Security Overlay (RSO) of ArchiMate. An ontological investigation of this artifact would reveal its adequacy, capabilities, and limitations w.r.t. the domain of risk and security. Based on that, a language redesign can be proposed as a refinement. Such analysis and redesign have been (...) executed for the risk elements of the RSO grounded in the Common Ontology of Value and Risk. The next step along this line of research is to address the following research problems: What would be the outcome of an ontological analysis of security-related elements of the RSO? That is, can we identify other semantic deficiencies in the RSO through an ontological analysis? Once such an analysis is provided, can we redesign the security elements of the RSO accordingly, in order to produce an improved artifact? Here, with the aid of the Reference Ontology for Security Engineering (ROSE) and the ontological theory of prevention behind it, we address the remaining gap by proceeding with an ontological analysis of the security-related constructs of the RSO. The outcome of this assessment is an ontology-based redesign of the ArchiMate language regarding security modeling. In a nutshell, we report the following contributions: (1) an ontological analysis of the RSO that identifies six limitations concerning security modeling; (2) because of the key role of the notion of prevention in security modeling, the introduction of the ontological theory of prevention in ArchiMate; (3) a well-founded redesign of security elements of ArchiMate; and (4) ontology-based security modeling patterns that are logical consequences of our proposal of redesign due to its underlying ontology of security. As a form of evaluation, we show that our proposal can describe risk treatment options, according to ISO 31000. Finally, besides presenting multiple examples, we proceed with a real-world illustrative application taken from the cybersecurity domain. (shrink)

IntroductionTranscranial magnetic stimulation is a consolidated procedure for the treatment of depression, with several meta-analyses demonstrating its efficacy. Theta-burst stimulation is a modification of TMS with similar efficacy and shorter session duration. The geriatric population has many comorbidities and a high prevalence of depression, but few clinical trials are conducted specifically for this age group. TBS could be an option in this population, offering the advantages of few side effects and no pharmacological interactions. Therefore, our aim is to investigate the (...) efficacy of TBS in geriatric depression.Clinical trial registration[https://clinicaltrials.gov/ct2/], identifier [NCT04842929]. (shrink)